
英文名称:IL-2 (C145S), Human, Recombinant
货号:GPCK021
价格: ¥3880.00 ¥1180.00 ¥420.00 ¥5680.00
产品详情
500μg / 50μg / 10μg / 1mg
物种Human
表达宿主E.coli
PHPro22-Thr153 (Cys145Ser)
序列信息Pro22-Thr153 (Cys145Ser)
检索号P60568
分子量15.5 kDa
表观分子量14 kDa
生物活性Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is 90-270 pg/mL.
纯度> 95% as determined by reducing SDS-PAGE.
内毒素< 0.1 EU/μg
制剂Lyophilized from a 0.2 μm filtered solution of 10 mM Acetata-Na, 5% Trehaiose, pH 4.5.
复融Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件Ambient temperature or ice pack.
有效期12个月
背景介绍Recombinant Human Interleukin-2 is a highly purified protein with a molecular weight of approximately 15,300 Daltons. The chemical name is des-alanyl-1, serine-145 Human Interleukin-2. It is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the Human IL-2 gene, and the resulting expression clone encodes a modified Human IL-2. This recombinant form differs from native Interleukin-2 in following ways: it is not glycosylated; the molecule has serine substituted for cysteine at amino acid position 145; the aggregation state of molecule is likely to be different from that of native IL-2.
相关文献
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期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2025.114394
影响因子:4.8
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DOI:10.1590/1414-431X2024e14187
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