500μg / 50μg / 10μg / 1mg

Human

Human Cells

Thr23-Asp159

Thr23-Asp159

P37173

42.6 kDa

59 kDa

C-Fc

Measured by its ability to inhibit TGF-beta 1 activity on TF-1 human erythroleukemic cells. The ED50 for this effect is 18.41 ng/mL in the presence of 100 pg/mL of recombinant human TGF-beta 1.

> 95% as determined by reducing SDS-PAGE.

< 0.1 EU/μg

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.

Ambient temperature or ice pack.

12个月

TGFBR2 is a single-pass type I membrane Protein and contains one Protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another Receptor Protein and binds TGF-beta. Signals triggered through the TGF-beta Receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on this action, the TGF-beta Receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors.