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VEGF/VEGF-A, Rat, Recombinant-1

英文名称：VEGF/VEGF-A, Rat, Recombinant

货号：GPCK266

价格： ￥11880.00 ￥2780.00 ￥880.00 ￥17280.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 Yeast
序列信息 Ala27-Arg190 (Ala36Thr)
检索号 P16612-2
分子量 19.2 kDa
表观分子量 18-23 kDa
生物活性 Immobilized Rat VEGF 164 at 2 μg/mL (100 μL/well) can bind Mouse VEGFR2-Fc. The ED50 of Mouse VEGFR2-Fc is 22.17 ng/mL.
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Vascular endothelial Growth Factor (VEGF/VEGF-A) is originally known as vascular permeability factor (VPF). It belongs to the PDGF family with a cysteine-knot structure comprised of eight conserved cysteine residues, and reckoned as a potent mediator in the process of angiogenesis and vasculogenesis in either fetus or adult. VEGF is particularly expressed in supraoptic, paraventricular nuclei and the choroid plexus of the pituitary, and abundant in the corpus luteum of the ovary and in kidney glomeruli. The rat VEGF Protein contains a putative 20 amino acids (aa) signal peptide, and alternative splicing of rat VEGF gene produces isoforms of 120, 144, 164 and 188 aa. Rat VEGF164 respectively displays 97% and 88% aa identity with that regions of mouse and human VEGF. VEGF can bind to the FLT1/VEGFR1 and KDR/VEGFR2 Receptors, heparan sulfate and heparin, and play important roles in inducing endothelial cell proliferation, promoting cell migration, inhibiting apoptosis and inducing permeabilization of blood vessels.
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