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IL-1R-2/CD121b (C-Fc), Human, Recombinant-1

英文名称：IL-1R-2/CD121b (C-Fc), Human, Recombinant

货号：GPCK146

价格： ￥11880.00 ￥1880.00 ￥780.00 ￥17280.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 Human Cells
序列信息 Phe14-Glu343
检索号 P27930
分子量 64.5 kDa
表观分子量 80-95 kDa
标签 C-Fc
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Interleukin-1 Receptor type 2 (IL1R2) belongs to the Interleukin-1 Receptor family. Two distinct types of IL1 Receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 Receptor type II is a 68 kDa transmembrane Protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signaling Receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy Receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble Receptors.
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