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TPO/THPO (N-6His), Mouse, Recombinant-1

英文名称：TPO/THPO (N-6His), Mouse, Recombinant

货号：GPCK098

价格： ￥12880.00 ￥3480.00 ￥1180.00 ￥18880.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品形态 粉末
产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 Human Cells
序列信息 Ser22-Thr356
检索号 P40226
分子量 36.4 kDa
表观分子量 65-105 kDa
标签 N-6His
生物活性 Measured in a cell proliferation assay using MO7E human megakaryocytic leukemic cells. The ED50 for this effect is 0.60 ng/mL.
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, 2 mM EDTA, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Thrombopoietin (TPO) is a glyco Protein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. Mature mouse Tpo shares 71% and 81% aa sequence homology with human and rat Tpo, respectively. It is an 80-85 kDa Protein that consists of an N-terminal domain with homology to Erythropoietin (Epo) and a C-terminal domain that contains multiple N-linked and O-linked glycosylation sites. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific Cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
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