请输入关键词！

文献(1) 说明书
一键复制产品信息
HGF R/c-Met/HGFR, Human, Recombinant-1

英文名称：HGF R/c-Met/HGFR, Human, Recombinant

货号：GPCK028

价格： ￥5680.00 ￥1180.00 ￥420.00 ￥8280.00

规格：
500μg 50μg 10μg 1mg
产品详情

产品信息

产品形态 粉末
产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 Human Cells
序列信息 Glu25-Thr932
检索号 P08581
分子量 102.5 kDa
表观分子量 130&80-95&40-50 KDa
标签 C-6His
生物活性 Immobilized Recombinant Human HGF-6His at 10 μg/mL (100 μL/well) can bind Human HGF R-His*. Biotinylated by NHS-biotin prior to testing The ED50 of Recombinant HGF R-His* is 9.47 μg/mL.
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Hepatocyte Growth Factor Receptor (HGF R) is a glycosylated Receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the α and β chains. The sema domain, which is formed by both α and β chains of HGF R, mediates both Ligand binding and Receptor dimerization. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells.
产品推荐
-产品推荐-2
-产品推荐-2
-产品推荐-2
-产品推荐-2
-产品推荐-2
-产品推荐-2
联系我们
sales@procell.com.cn
400-999-2100
相关推荐
×
确定