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APRIL/TNFSF13/TRDL-1α (N-Flag-His), Human, Recombinant-1

英文名称：APRIL/TNFSF13/TRDL-1α (N-Flag-His), Human, Recombinant

货号：GPCK107

价格： ￥14680.00 ￥1680.00 ￥780.00 ￥19680.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 Human Cells
序列信息 Lys112-Leu250
检索号 O75888
分子量 50 kDa
表观分子量 60 kDa
生物活性 Immobilized Human APRIL -Flag-His at 1 μg/mL (100 μL/well) can bind Cynomolgus BCMA-Fc. The ED50 of Cynomolgus BCMA-Fc is 4.23 ng/mL.
纯度 > 90% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 1 M NaCl, pH 8.3.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 APRIL (a proliferation-inducingLigand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF Ligand superfamily. It issynthesized as a32 kDa pro Protein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule.Secreted human APRIL, which consists almost entirely ofa single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. BothAPRIL and its close relative BAFF bind and signalthrough the TNF superfamily Receptors TACI and BCMA, while BAFF additionally functions through BAFF R.APRIL binds to heparan sulfateproteoglycans (HSPGs) independently of its binding to TACI and BCMA.
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