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IL-13 (Pro22-Phe131, C-6His), Mouse, Recombinant-1

英文名称：IL-13 (Pro22-Phe131, C-6His), Mouse, Recombinant

货号：GPCK252

价格： ￥14680.00 ￥3480.00 ￥1180.00 ￥23880.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 Human Cells
序列信息 Pro22-Phe131
检索号 P20109
分子量 13.1 kDa
表观分子量 14-30 kDa
标签 C-6His
生物活性 Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 2-13 ng/mL.
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Mouse Interleukin 13 (mIL-13) is a pleiotropic Cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human Protein and exhibits cross-species activity. IL13 signals via Receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric Receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.
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