M-CSF/CSF-1/MGI-IM, Mouse, Recombinant -

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M-CSF/CSF-1/MGI-IM, Mouse, Recombinant-1

英文名称：M-CSF/CSF-1/MGI-IM, Mouse, Recombinant

货号：GPCK303

规格：

50μg 10μg

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产品信息

产品形态	粉末
产品规格	50μg / 10μg
表达宿主	E.coli
序列信息	MKEVSEHCSHMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSSRDVVTKP withpolyhistidine tag at the C-terminus
检索号	Q9QYH9.1
分子量	19.02 kDa
表观分子量	17-25 kDa
标签	His-tag at the C-terminus
生物活性	Measure by its ability to induce proliferation in NFS-60 cells.The ED50 for this effect is < 2 ng/mL. The specific activity of recombinant mouse M-CSF is approximately > 5 × 10^5 IU/mg.
纯度	> 98% as determined by SDS-PAGE. Ni-NTA chromatography.
内毒素	< 0.1 EU/μg
制剂	The protein was lyophilized from a 0.2 μm filtered solution containing 1 × PBS, pH 8.0.
复融	It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.
储存条件	Lyophilized protein should be stored at -5~-20℃ for 1 year. Upon reconstitution, store at 2-8℃ for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10% FBS, 5% HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20℃ or -80℃ for 3-6 months.
运输条件	Ambient temperature or ice pack.
有效期	12个月
背景介绍	Macrophage Colony-Stimulating Factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

相关文献

A self-assembled bilayer polypeptide-engineered hydrogel for spatiotemporal modulation of bactericidal and anti-inflammation process in osteomyelitis treatment(2022)

期刊：JOURNAL OF NANOBIOTECHNOLOGY

DOI：10.1186/s12951-022-01614-3

影响因子：9.429

相关产品： RPMI-1640 Medium, M-CSF/CSF-1/MGI-IM, Human, Recombinant

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