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IL-23/NKSF2 (C-6His), Human, Recombinant-1

英文名称：IL-23/NKSF2 (C-6His), Human, Recombinant

货号：GPCK187

价格： ￥11880.00 ￥3480.00 ￥1180.00 ￥18880.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 Human Cells
序列信息 Arg20-Pro189&Ile23-Ser328
检索号 Q9NPF7&P29460
分子量 19.7&34.8 kDa
表观分子量 19-21&40-60 kDa
标签 C-6His
生物活性 Measured by its ability to induce STAT reporter activity in 293F human embryonic kidney cells. The ED50 for this effect is 70-210 ng/mL.
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 200 mM Trehalose, 4% Mannitol, 50 mM NaCl, 0.02% Tween80, pH 7.5.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Interleukin 23 (IL-23) is a heterodimeric Cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain Cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic Cytokine Receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
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