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IL-4Ra (C-6His), Cynomolgus, Recombinant-1

英文名称：IL-4Ra (C-6His), Cynomolgus, Recombinant

货号：GPCK104

价格： ￥11880.00 ￥2280.00 ￥780.00 ￥17280.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 Human Cells
序列信息 Met26-Arg232
检索号 G7Q0S7
分子量 24.6 kDa
表观分子量 38-58kDa
生物活性 Measured by its ability to inhibit IL-4-dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 2.38 ng/mL.
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Interleukin-4 Receptor subunit alpha (IL-4RA), alos known as Soluble IL-4 Receptor subunit alpha, belongs tothe type I Cytokine Receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functionsas Receptor for both Interleukin 4 and Interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgEproduction and Chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin Receptor substrates, IRS1/IRS2. The functional IL4 Receptor isformed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gammachain. In immune cells, IL-4RA creates a type I Receptor. In non-immune cells, it forms a type II Receptorwith of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II Receptor andinteracts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.
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