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IL-1R-1/CD121a (C-Fc), Human, Recombinant-1

英文名称：IL-1R-1/CD121a (C-Fc), Human, Recombinant

货号：GPCK145

价格： ￥11880.00 ￥1880.00 ￥780.00 ￥17280.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 Human Cells
序列信息 Leu18-Thr332
检索号 P14778
分子量 62.9 kDa
表观分子量 80-105 kDa
标签 C-Fc
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Interleukin 1 Receptor, type I (IL-1R1) is an Interleukin Receptor that belongs to the Interleukin-1 Receptor family. IL-1R1 is an 80 kDa transmembrane Protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and IL1RL1 form a Cytokine Receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many Cytokine induced immune and inflammatory responses. It binds to Interleukin-1 associates with the corecptor IL1RAP to form the high affinity Interleukin-1 Receptor complex which mediates Interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the Receptor/coReceptor subunits. It also binds Ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. An IL1 Receptor accessory Protein that can heterodimerize with the Type I Receptor in the presence of IL1α or IL1β but not IL1ra, was identified. Recombinant IL1 soluble Receptor Type I is a potent antagonist of IL1 action.
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