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Heregulin-β1, Human, Recombinant-1

英文名称：Heregulin-β1, Human, Recombinant

货号：GPCK373

价格： ￥11880.00 ￥1880.00 ￥780.00 ￥16880.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品形态 粉末
产品规格 500μg / 50μg / 10μg / 1mg
别名 Pro-neuregulin-1; Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1; EGF;NRG1;GGF;HGL;HRGA;NDF;SMDF;Heregulin-β1
表达宿主 E.coli
序列信息 A DNA sequence encoding Human Heregulin Beta 1 Protein (#Q02297-6) (Ser177-Glu241) was expressed with polyhistidine tag at the C-terminus.
检索号 Q02297-6
分子量 8.42 kDa
表观分子量 8 kDa
标签 His Tag (C-term)
生物活性 Measure by its ability to induce MCF-7 cells proliferation. The ED for this effect is < 10 ng/mL.
纯度 >95% as determined by SDS-PAGE. Ni-NTA chromatography.
内毒素 < 0.1 EU/μg
制剂 The protein was lyophilized from a 0.2 μm filtered solution containing 1 × PBS, pH8.0.
复融 It is recommended to reconstitute the lyophilized protein in sterile water to aconcentration not less than 100 μg/mL. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.
储存条件 Lyophilized protein should be stored at -5~-20℃ for 1 year. Upon reconstitution, store at 2-8℃ for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10% FBS, 5% HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20℃ or -80℃ for 3-6 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Neuregulin-1 (NRG-1, also called heuregulin1 or neu differentiation factor) is a glycoprotein that belongs to the neuregulins family. Structurally, Neuregulin-1 harbors tissue-speci?c N terminal sequence, followed by immunoglobulin-like (Ig-like) domains, an EGF-like domain, a transmembrane domain, and a cytoplasmic domain. NRG1 has multiple isoforms produced by alternative splicing. Heregulin-β1 (HRG-β1) is one of the isoforms, has been reported to engage the development and survival of cardiomyocytes derived from embryonic stem (ES) cells via activating MAPK-ERK and PI3K-AKT pathways. Moreover, HRG-β1 plays a central role in promoting the proliferation of neuronal progenitors from embryonic neural stem cells.
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