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CD40L/TNFSF5/TRAP/CD154, Human, Recombinant-1

英文名称：CD40L/TNFSF5/TRAP/CD154, Human, Recombinant

货号：GPCK290

价格： ￥680.00

规格：
10μg
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产品信息

产品规格 10μg
表达宿主 E.coli
序列信息 MQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL with polyhistidine tag at the C-terminus
检索号 P29965
分子量 16.99 kDa
表观分子量 16 kDa
标签 His-tag at the C-terminus
生物活性 Measure by its ability to induce IL-8 secretion in human PBMCs. The ED50 for this effect is < 5 ng/mL.
纯度 > 95% as determined by SDS-PAGE. Ni-NTA chromatography.
内毒素 < 0.1 EU/μg
制剂 The protein was lyophilized from a 0.2 μm filtered solution containing 1 × PBS, pH 8.0.
复融 It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.
储存条件 Lyophilized protein should be stored at -5~-20℃ for 1 year. Upon reconstitution, store at 2-8℃ for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10% FBS, 5% HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20℃ or -80℃ for 3-6 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 CD40, belonging to the TNF receptor family, is a cell surface protein generally expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and on T cells at low levels. The membrane-anchored CD40 Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. CD40 signaling plays a significant role immunoglobulin (Ig) class switching, and is critical for the proliferation and differentiation of B cells. A disease "immunodeficiency with hyper-IgM", characterized by failure to produce IgG, IgA and IgE due to failure expression of CD40L. The soluble form of CD40L is produced in vivo by an intracellular proteolytic processing of the entire TNF homologous region (18 kDa protein) of CD40L.
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