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pro-BDNF/BDNF, Human, Recombinant-1

英文名称：pro-BDNF/BDNF, Human, Recombinant

货号：GPCK084

价格： ￥11880.00 ￥2280.00 ￥780.00 ￥17280.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 E.coli
序列信息 Ala19-Arg247 (R125A,R127A,R128A)
检索号 P23560
分子量 25.6 kDa
表观分子量 28 kDa
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Supplied as a 0.2 μm filtered solution of 20 mM PB, 10% Trehalose, 100 mM NaCl, 0.02% Tween 80, pH 6.0.
储存条件 Store at ≤-70℃, stable for 6 months after receipt. Store at ≤-70℃, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输条件 The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
有效期 6个月
背景介绍 The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin Receptor p75 (p75NTR) and vps10p domain-containing Receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase Receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
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