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IL-36α, Human, Recombinant-1

英文名称：IL-36α, Human, Recombinant

货号：GPCK194

价格： ￥14680.00 ￥4280.00 ￥1680.00 ￥19680.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
别名 Interleukin-36 Alpha;FIL1 Epsilon;Interleukin-1 Epsilon;IL-1 Epsilon;Interleukin-1 Family Member 6;IL-1F6;IL36A;FIL1E;IL1E;IL1F6
表达宿主 E.coli
序列信息 Lys6-Phe158
检索号 Q9UHA7
分子量 17.1 kDa
表观分子量 17 kDa
生物活性 Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is 1.83 ng/mL.
纯度 > 95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 EU/μg
制剂 Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 6% Trehalose, 5 mM EDTA, 0.05% Tween 80, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输条件 Ambient temperature or ice pack.
有效期 12个月
背景介绍 Human Interleukin-36α (IL-36α) is a secreted Cytokine that belongs to the Interleukin 1 Cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this Cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding Receptor which upon ligation, recruits a second Receptor as a signaling component, forming an active heterodimeric Receptor complex.
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