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Purified Anti-Human CD74 Antibody[LN2]

文献(1) 说明书
  • Purified Anti-Human CD74 Antibody[LN2]-1
  • Purified Anti-Human CD74 Antibody[LN2]-2
Purified Anti-Human CD74 Antibody[LN2]-1

货号:GF1072A

价格: ¥1230.00 ¥3680.00

规格:
100 μg 1 mg
产品详情
Background

CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

Alternate Names

HLA class II histocompatibility antigen gamma chain;HLADG;Ia antigen-associated invariant chain;Ia-GAMMA II;Ii;p33;CD74 HLA-DR antigens-associated invariant chain;DHLAG;CD74; invariant chain;CD 74;CD74 antigen;CD74 antigen (invariant polypeptide of major histocompatibility complex;CD74 molecule;class II antigen-associated);class II invariant chain;CLIP;Gamma chain of class II antigens;HG2A;HLA DR antigens associated invariant chain;HLA DR gamma;HLADR antigens associated invariant chain;HLA-DR antigens-associated invariant chain;HLA-DR-gamma;Ia antigen associated invariant chain;Ia associated invariant chain;Ia gamma;Ia-GAMMA;Invariant polypeptide of major histocompatibility complex class II antigen associated;la-gamma;major histocompatibility complex;Major histocompatibility complex class II invariant chain;MHC HLA DR gamma chain;MHC HLA-DR gamma chain;p35;Protein 41;CD74;DHLAG;HLA class II histocompatibility antigen gamma chain;HLADG;Ia antigen-associated invariant chain;p33;CD 14;CD_antigen=CD14;CD14;CD14 antigen;CD14 molecule;LPS-R;Mo2;Monocyte differentiation antigen CD14;Monocyte differentiation antigen CD14 urinary form;membrane-bound form;Myeloid cell specific leucine rich glycoprotein;Myeloid cell-specific leucine-rich glycoprotein

Swissprot

P04233

Immunogen

Recombinant Human CD74 protein

Clone No.

LN2

Host

Mouse

Reactivity

Human

Isotype

Mouse IgG1, κ

Dilution

FCM 2 μg/mL(1×105-5×105 cells)

Conjugate

Unconjugated

Concentration

≥ 1 mg/mL

Purification Method

>98%, Protein A/G purified

Applications

FCM

Clonality

Monoclonal

Storage Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Storage

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiration Date

12个月

Shipping

Ice bag

产品结果图

Purified Anti-Human CD74 Antibody[LN2]-产品结果图-1

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