Recombinant Mouse CD40/TNFRSF5 Protein(His Tag)

说明书

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Recombinant Mouse CD40/TNFRSF5 Protein(His Tag)-1

货号：GPMM0170

规格：

500 μg 100 μg 20 μg 1 mg

产品详情

Abbre

CD40/TNFRSF5

Alternate Names

IMD;B-cell surface antigen CD;Tumor necrosis factor receptor superfamily member;HIGM;Tnfrsf;HIGM1;I326936;IGM;IMD3;p50;T-BAM;TRAP;Bp50;CD40;Tnfrsf5;Tumor necrosis factor receptor superfamily member 5;B-cell surface antigen CD40;CD40L receptor;gp39 R;TNFRSF5;CD40 (protein);CD40 molecule;CDW40

Calculated Mw

19 kDa

Observed Mw

30 kDa

Swissprot

P27512

Background

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thoμght to be an early event in Alzheimer disease pathogenesis.

Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.