Recombinant Human Sclerostin/SOST Protein(His Tag)

说明书

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Recombinant Human Sclerostin/SOST Protein(His Tag)-1

货号：GPMH0124

规格：

500 μg 100 μg 20 μg 1 mg

产品详情

Abbre

Sclerostin

Alternate Names

CDD;DAND6;SOST1;VBCH

Calculated Mw

23.3 kDa

Observed Mw

35 kDa

Swissprot

Q9BQB4

Background

Sclerostin, also known as SOST, is a member of the Cerberus/DAN family of BMP antagonists. SOST is asecreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain. It shows sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. SOST is produced by the osteocyte and has anti-anabolic effects on bone formation. It is a negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.