Recombinant Human IL6RA/CD126 Protein(His Tag)

IL6RA

Membrane glycoprotein;CD126;gp80;IL6Q;IL-6R;IL-6R 1;IL-6R subunit alpha;IL-6R-1;IL6RA;IL-6RA;IL-6R-Alpha;IL6RQ;Interleukin-6 receptor subunit alpha;Membrane glycoprotein 80;IL6R;IL-6Rαalpha;CD 126;CD126 antigen;IL 6R;IL 6R 1;IL 6R alpha;IL-6 receptor alpha chain;IL-6 receptor subunit alpha;IL-6R 1 Membrane glycoprotein 80 (gp80);Interleukin 6 receptor;MGC30256

40.0 kDa

65 kDa

P08887

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.