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R-spondin 1/RSPO1, Human, Recombinant-1

英文名称：R-spondin 1/RSPO1, Human, Recombinant

货号：GPCK214

价格： ￥11880.00 ￥2280.00 ￥780.00 ￥17280.00

规格：
500μg 50μg 10μg 1mg
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产品信息

产品规格 500μg / 50μg / 10μg / 1mg
表达宿主 HEK293
序列信息 A DNA sequence encoding Human R-Spondin 1 Protein (#Q2MKA7) (Ser21-Ala263) was expressed with polyhistidine-SUMO tag at the N-terminus.
检索号 Q2MKA7
分子量 42.43 kDa
表观分子量 68 kDa
标签 His-SUMO tag at the N-terminus
生物活性 R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The ED50 for this effect is 1-3 μg/mL.
纯度 > 95% as determined by SDS-PAGE. Ni-NTA chromatography.
内毒素 < 0.1 EU/μg
制剂 Liquid (1 × PBS, pH 7.4)
储存条件 Store at -5~-20℃ or -80℃ for 6 months. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10% FBS, 5% HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20℃ or -80℃ for 3-6 months.
运输条件 The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
有效期 12个月
背景介绍 R-spondin 1 (RSPO1, Roof plate-specific Spondin 1) is a cysteine-rich secreted glycoprotein that belongs to the R-Spondin family. Structurally, R-spondin 1 harbors an N-terminal signal peptide, two cysteine-rich furin-like (FU1-FU2) domains, a thrombospondin (TSP) domain, and a basic amino acid-rich (BR) C-terminal domain. R-spondin 1 acts as a ligand for the leucine-rich repeat-containing G-protein coupled receptor (LGR) family (LGR4/5/6), subsequent clearing negative regulators ZNRF3/RNF43 from the membrane, leading to the availability of Wnt receptor and activating Wnt/β-catenin signaling. The signal cascade is essential for regulating stem cell proliferation, embryonic development, and tissue homeostasis.
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