Purified Anti-Human CD8a Antibody[OKT-8]

CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

Leu;T-lymphocyte differentiation antigen T8/Leu;CD8A;CD8;Leu2;MAL;p32;T8;T-cell surface glycoprotein CD8 alpha chain;T-lymphocyte differentiation antigen T8/Leu-2; CD8; Leu-2; Ly-2;alpha polypeptide (p32);CD8 antigen alpha polypeptide;CD8 antigen alpha polypeptide (p32);CD8A antigen;CD8A molecule;Leu2 T lymphocyte antigen;Ly3;LYT3;OKT8 T cell antigen;OTTHUMP00000160760;OTTHUMP00000160764;OTTHUMP00000203528;OTTHUMP00000203721;T cell antigen Leu2;T cell co receptor;T8 T cell antigen;T8/Leu-2 T-lymphocyte differentiation antigen

P01732

Recombinant Human CD8a protein

OKT-8

Mouse

Human

Mouse IgG2a, κ

FCM 2 μg/mL(1×10⁵-5×10⁵ cells)

Unconjugated

≥ 1 mg/mL

>98%, Protein A/G purified

FCM

Monoclonal

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

12个月

Ice bag