PE Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]

文献(11) 说明书

货号：GFH1351D

规格：

100 Tests 50 Tests 100 Tests × 2

产品详情

Background

FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4⁺/CD25^- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.

Alternate Names

IPEXJM2ScurfinZinc finger protein JM2;Forkhead box protein P3

Swissprot

Q99JB6

Clone No.

FJK-16s

Host

Rat

Reactivity

Mouse;Rat

Isotype

Rat IgG2a, κ

Conjugate

Applications

ICFCM

Clonality

Monoclonal

Storage Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Expiration Date

12个月

Shipping

冰袋

产品结果图

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