PE Anti-Mouse IL-17A Antibody[TC11-18H10.1]

文献(11) 说明书

货号：GFH1199D

规格：

100 Tests 50 Tests 100 Tests × 2

产品详情

Background

IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Alternate Names

CTLA-8;CTLA8;Cytotoxic T-lymphocyte-associated antigen 8;IL-17;IL-17A;Interleukin-17A

Swissprot

Q62386

Clone No.

TC11-18H10.1

Host

Rat

Reactivity

Mouse

Isotype

Rat IgG1, κ

Conjugate

Concentration

5 μL/Test

Applications

ICFCM

Clonality

Monoclonal

Storage Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Expiration Date

12个月

Shipping

冰袋

产品结果图

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