500μg / 50μg / 10μg / 1mg

Human

Human Cells

Ser19-Asn178

Ser19-Asn178

P22301

18.6 kDa

16 kDa

Loaded Human IL-10RA-His on HIS1K Biosensor, can bind Human IL-10 with an affinity constant of 1 pM as determined in BLI assay.

> 95% as determined by reducing SDS-PAGE.

< 0.1 EU/μg

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in sterile water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.

Ambient temperature or ice pack.

12个月

Interleukin 10 (IL10), also known as Cytokine synthesis inhibitory factor (CSIF),is a secreted Protein and belongs to the IL-10 family. IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts . IL-10 is an anti-inflammatory TH2 Cytokine that has a critical role in limiting the immune response to pathogens to prevent host damage. As IL-10 in produced in several T helper populations, it is proposed that it provides a feedback loop to limit the effector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10 Receptor (IL-10R) to activate STAT3. As IL-10 is a strong inhibitor of inflammation, it has become a viable biomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions. In addition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviral infections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations