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APC Anti-Mouse Foxp3 Antibody[3G3]

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  • APC Anti-Mouse Foxp3 Antibody[3G3]-1
APC Anti-Mouse Foxp3 Antibody[3G3]-1

货号：GFH1238E

价格： ￥3168.00 ￥2088.00 ￥4752.00

规格：
100 Tests 50 Tests 100 Tests × 2
产品详情
Background

FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.

Alternate Names

Forkhead box protein P3;Foxp3;IPEX;JM2

Swissprot

Q99JB6

Clone No.

3G3

Host

Mouse

Reactivity

Mouse

Isotype

Mouse IgG1, κ

Conjugate

APC

Concentration

5 μL/Test

Applications

ICFCM

Clonality

Monoclonal

Storage Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.

Storage

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Expiration Date

12个月

Shipping

冰袋

产品结果图

APC Anti-Mouse Foxp3 Antibody[3G3]-产品结果图-1

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