AF/LE Purified Anti-Mouse CD22 Antibody[Cy34.1]
货号:GF10210
价格: ¥420.00 ¥1248.00
产品详情
The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig μ chain are augmented in the presence of Cy34.1 mAb.
Alternate NamesLyb;SIGLEC2FLJ;B-cell receptor CD;T-cell surface antigen Leu;sialic acid binding Ig-like lectin;Sialic acid-binding Ig-like lectin;B-cell receptor CD22;BL-CAM;B-lymphocyte cell adhesion molecule;CD22 antigenMGC130020;CD22 molecule;sialic acid binding Ig-like lectin 2;Sialic acid-binding Ig-like lectin 2;Siglec-2;SIGLEC2FLJ22814;T-cell surface antigen Leu-14;Lyb-8;Siglec2;Cd22; Lyb8; Siglec-2
Swissprot ImmunogenRecombinant Mouse CD22 protein
Clone No. HostMouse
ReactivityMouse
IsotypeMouse IgG1, κ
DilutionFCM 2 μg/mL(1×105-5×105 cells)
ConjugateNone (AF/LE)
Concentration≥ 1 mg/mL
Purification Method>98%, Protein A/G purified
ApplicationsFCM
ClonalityMonoclonal
Storage BufferSterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
StorageStore at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Expiration Date12个月
ShippingIce bag