Recombinant Rat IL-1α/IL-1F1 Protein(Trx Tag)

IL-1α/IL-1F1

interleukin;Hematopoietin;IL1F1hematopoietin;IL1F;IL-1F;alpha;BAF;Hematopoietin-1;IL1;IL1 alpha;IL-1 alpha;IL1-A;IL-1A;IL1-ALPHA;IL1F1;IL-1F1;IL1F1hematopoietin-1;interleukin 1;interleukin-1 alpha;LAF;LEM;preinterleukin 1 alpha;pro-interleukin-1-alpha;Il1a;FAF;Hematopoietin 1;IL 1 alpha;IL 1A;IL1;IL1 ALPHA;IL1F1;Interleukin 1 alpha;LAF;LEM;Preinterleukin 1 alpha;Il1a

37 kDa

35 kDa

P16598

IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T-and B-cells) immune systems. Cytokines can be classified into two groups: pro-and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6, and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.