Recombinant Mouse IL-23A Protein(Fc Tag)

IL-23a

IL 23;IL 23 A;IL 23 subunit alpha;IL 23A;IL 23p19;IL-23 subunit alpha;IL-23-A;IL-23p19;IL12B;IL23;Il23a;IL23A_HUMAN;IL23P19;interleukin 12B;Interleukin 23 alpha subunit p19;Interleukin 23 p19 subunit;interleukin 23 subunit alpha;interleukin 23 subunit p19;interleukin six, G CSF related factor;Interleukin-23 subunit alpha;Interleukin-23 subunit p19;JKA3 induced upon T cell activation;MGC79388;P19;SGRF

44.1 kDa

40-50 kDa

Q9EQ14

IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.