Recombinant Mouse CD117/c-kit Protein(Fc Tag)

CD117/c-kit

SOW;Gsfsow;SCO;W;Bs;Fdc;Ssm;SCO1;SCO5;SOW3;CD117;c-KIT;Tr-kit;Gsfsco1;Gsfsco5;Gsfsow3;Mast/stem cell growth factor receptor Kit;Proto-oncogene c-Kit;SCFR;Tyrosine-protein kinase Kit;Sl;Kit;SCFR;CD117;c-KIT;Fdc;Gsfsco1;Gsfsco5;Gsfsow3;SCO1;SCO5;SOW3;Ssm;Tr-kit;KIT proto-oncogene receptor tyrosine kinase;PBT

80.2 kDa

90 kDa

P05532

C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily, tyr protein kinase family, and CSF-1/PDGF receptor subfamily. C-Kit has tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase. Antibodies to c-Kit are widely used in immunohistochemistry to help distinguish particular types of tumor in histological tissue sections. It is used primarily in the diagnosis of GISTs. In GISTs, c-Kit staining is typically cytoplasmic, with stronger accentuation along the cell membranes. C-Kit antibodies can also be used in the diagnosis of mast cell tumors and in distinguishing seminomas from embryonal carcinomas. Mutations in the c-Kit gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Defects in KIT are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Note=Somatic mutations that lead to constitutive activation of KIT are detected in AML patients.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.