Recombinant Human CDH1 Protein(His Tag)

CDH1

CDH;Arc;CADH;CD antigen CD;Cleaved into: E-Cad/CTF;Cadherin;CAM 120/;Arc-1;CD324;CDHE;ECAD;LCAM;UVO;CDH1;E-Cadherin;CADH1;Cadherin-1;Uvomorulin;E-Cad;CTF2;CAM 120/80;Epithelial cadherin;CD antigen CD324;Cleaved into: E-Cad/CTF1;CTF3;CDH1;Arc 1;Arc 1;CADH1;Cadherin 1;cadherin 1 type 1 E-cadherin;Cadherin1;CAM 120/80;CD 324;CD324;CD324 antigen;cdh1;CDHE;E-Cad/CTF3;E-cadherin;ECAD;Epithelial cadherin;epithelial calcium dependant adhesion protein;LCAM;Liver cell adhesion molecule;UVO;Uvomorulin;Arc-1;Cadherin 1;cadherin 1 type 1 E-cadherin;Cadherin1;CD 324;CD324 antigen;E-Cad/CTF3;epithelial calcium dependant adhesion protein;Liver cell adhesion molecule

61.1 kDa

75-80 kDa

P12830

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.