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Purified Anti-Human TRAV12-1 Antibody[S511]

说明书
  • Purified Anti-Human TRAV12-1 Antibody[S511]-1
  • Purified Anti-Human TRAV12-1 Antibody[S511]-2
Purified Anti-Human TRAV12-1 Antibody[S511]-1

货号:GF003730P

价格: ¥1230.00 ¥3680.00

规格:
100 μg 1 mg
产品详情
Background

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Alternate Names

TRAV12-;TRAV12-1

Swissprot

A0A0B4J245

Immunogen

Recombinant Human TRAV12-1 protein

Clone No.

S511

Host

Mouse

Reactivity

Human

Isotype

Mouse IgG2b, κ

Dilution

FCM 2 μg/mL(1×105-5×105 cells)

Conjugate

Unconjugated

Concentration

≥ 1 mg/mL

Purification Method

>98%, Protein A/G purified

Applications

FCM

Clonality

Monoclonal

Storage Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Storage

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiration Date

12个月

Shipping

Ice bag

产品结果图

Purified Anti-Human TRAV12-1 Antibody[S511]-产品结果图-1

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