Purified Anti-Human HLA-A2 Antibody[BB7.2]

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

HLAA;HLA-A;HLA-A protein;MHC class I antigen A;MHC leukocyte antigen

P04439

Recombinant Human HLA-A2 protein

BB7.2

Mouse

Human

Mouse IgG2b, κ

Verified Samples in FCM: Human peripheral blood lymphocytes cell

FCM 2 μg/mL(1×10⁵-5×10⁵ cells)

Unconjugated

≥ 1 mg/mL

>98%, Protein A/G purified

FCM

Monoclonal

PBS, pH 7.2. Contains 0.05% Proclin300.

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

12个月

Ice bag