Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3]

CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

PDL;B7H;PD-L;PD1L;Programmed cell death 1 ligand;PDCD1L;PDCD1LG;B7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274;B7-H1;B7 homolog 1;CD274 molecule;PDCD1 ligand 1;Programmed death ligand 1;PD1L1;Programmed cell death 1 ligand 1; PDL1; PD-L1;B7-H;B7H1;CD274 molecule;PDCD1L1;PDCD1LG1;B7 H;B7 H1;CD 274;CD274 antigen;MGC142294;MGC142296;OTTHUMP00000021029;PD L1;PDL 1;RGD1566211

Q9NZQ7

Recombinant Human CD274/PD-L1 protein

29E.2A3

Mouse

Human

Mouse IgG2b, κ

FCM 2 μg/mL(0.5×10⁶-1×10⁶ cells)

Unconjugated

≥ 1 mg/mL

>98%, Protein A/G purified

FCM

Monoclonal

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

12个月

Ice bag