AF/LE Purified Anti-Mouse CD54 Antibody[YN1/1.7.4]

CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

MyD;P3.;MALA;ICAM-1/CD;MAL;CD54;Icam;Ly-4;Ly-47;Icam-1;MALA-2;BB2;ICAM-1/CD54;Intercellular adhesion molecule 1;MyD10;P3.58;Icam1; Ly-47; MALA-2;CD54;Icam;Icam-1;Ly-4

P13597

Recombinant Mouse CD54 protein

YN1/1.7.4

Rat

Mouse

Rat IgG2b, κ

FCM 2 μg/mL(1×10⁵-5×10⁵ cells)

None (AF/LE)

≥ 1 mg/mL

>98%, Protein A/G purified

FCM

Monoclonal

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

12个月

Ice bag