AF/LE Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98]

CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

CD115;CSF-1 receptor (EC:2.7.10.1);CSF-1R;CSF-1-R;Macrophage colony-stimulating factor 1 receptor;M-CSF-R;Proto-oncogene c-Fms;Csfmr;Fms;Csf1r;M-CSFR; c-fms; CSF-1R;AI323359;Fim-2

P09581

Recombinant Mouse CD115/CSF-1R protein

AFS98

Rat

Mouse

Rat IgG2a, κ

FCM 2 μg/mL(1×10⁵-5×10⁵ cells)

None (AF/LE)

≥ 1 mg/mL

>98%, Protein A/G purified

FCM

Monoclonal

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

12个月

Ice bag